■ １３.参考文献
1) Allen DG, Jewell BR, Murray JW: The contribution of activation processes
to the length-tension relation of cardiac muscle. Nature 1974;248:606-607.
2) Alpert BS, Benson L, Olley PM: Peak left ventricular pressure/volume
(Emax) during exercise in control subjects and children with left-sided cardiac
disease. Catheter Cardiovasc. Diagnos. 1981; 7:145-153.
3) Alpert NR, Mulieri LA, Litten RZ, Holubarsch C: A myothermal analysis
of the myosin crossbridge cycling rate during isometric tetanus in normal and
hypothyroid rat hearts. Europ. Heart J. 1984;5 (Suppl. F):3-11.
4) Applegate RJ, Cheng CP, Little WC: Simultaneous conductance catheter
and dimension assessment of left ventricle volume in the intact animal.
Circulation 1990;81:638-648.
5) Baan J, Jong TTA, Kerkhof P, Moene R, Van Dijk AD, Van der Velde E,
Koops J: Continuous stroke volume and cardiac output from intraventricular
dimensions obtained with impedence catheter. Cardiovasc. Res. 1981;15:328-
334.
6) Baan J, Van der Velde E, de Bruin H, Smeenk G, Koops J, Van Dijk A,
Temmerman D, Senden J, Buis B: Continuous measurement of left
ventricular volume in animals and humans by conductance catheter.
Circulation 1984;70:812-823.
7) Baan J, Van der Velde ET: Sensitivity of left ventricular end-systolic
pressure-volume relation to type of loading intervention in dogs. Circ. Res.
1988;62:1247-1258.
8) Barany M: ATPase activity of myosin correlated with speed of muscle
shortening. J. Gen. Physiol. 1967;50(No. 6 Pt 2):197-216.
9) Barclay JK, Gibbs CL, Loiselle DS: Stress as an index of metabolic cost in
papillary muscle of the cat. Basic. Res. Cardiol. 1979;74:594-603.
10) Barjon JN, Rouleau JL, Bichet D, Juneau C, De Champlain J: Chronic
renal and neurohormonal effects of the calcium entry blocker nisoldipine in
patients with congestive heart failure. J. Am. Coll. Cardiol. 1987;9:622-630.
11) Bayliss J, Noreel MS, Canepa-Anson R, Reid C, Poole-Wilson P, Sutton
G: Clinical importance of the renin-angiotensin system in chronic heart failure:
double-blind comparison of captopril and prazosin. Br. Med. J.
1985;290:1861-1865.
12) Bergel DH: The static elastic properties of the arterial wall. J. Physiol.
(Lond.) 1961;156:445-457.
13) Blinks J, Endoh M: Modification of myofibrillar responsiveness to Ca++ as
an inotropic mechanism. Circulation 1986;73 (Suppl. III):III 85-III 98.
14) Borow KM, Neumann A, Wynne J: Sensitivity of end-systolic pressuredimension
and pressure-volume relations to the inotropic state in humans.
Circulation 1982;65:988-997.
15) Boudoulas H, Beaver BM, Kates RE, Lewis RP: Pharmacodynamics of
inotropic and chronotropic responses to oral therapy with propranolol. Studies
in normal subjects and patients with angina. Chest 1978;73:146-153.
16) Bowditch H: Uber die Eignthumlichkeiten der Reizbarkeit, welche die
Muskelfasern des Herzens zeigen. Arb Physiol Anstalt zu Leipzig 1871;6:139-176.
17) Bowen WP: Changes in heart-rate, blood-pressure, and duration of systole
resulting from bicycling. Am. J. Physiol. 1904;11:59-77.
18) Bristow MR, Ginsburg R, Minobe W, Cubicciotti RS, Sageman WS,
Lurie K, Billingham ME, Harrison DC, Stinson EB: Decreased
catecholamine sensitivity and b-adrenergic receptor density in failing human
hearts. N. Engl. J. Med. 1982;307:205-211.
19) Burkhoff D, Sugiura S, Yue DT, Sagawa K: Contractility-dependent
curvilinearity of end-systolic pressure-volume relations. Am. J. Physiol.
1987;252:H1218-H1227.
20) Buyukozturk K, Kimbiris D, Segal BL: Systolic time intervals: relation to
severity of coronary artery disease, intercoronary collateralization and left
ventricular dyskinesia. Am. J. Cardiol. 1971;28:183-190.
21) Carliner NH, Gilbert CA, Pruitt AW, Goldberg LI: Effects of maintenance
digoxin therapy on systolic time intervals and serum digoxin concentrations.
Circulation 1974;50:94-98.
22) Chidsey CA, Harrison DC, Braunwald E: Augmentation of the plasma
nor-epinephrine response to exercise in patients with congestive heart failure.
N. Engl. J. Med. 1962;267:650-654.
23) Christensen NJ: The role of catecholamines in clinical medicine. Acta.
Med. Scand. 1979;624 (Suppl.):9-18.
24) Clark JH: The elasticity of vein. Am. J. Physiol. 1933;105:418.
25) Cohn JN, Archibald DG, Ziesche S, Franciosa JA, Harston WE, Tristani
FE, Dunkman WB, Jacobs W, Francis GS, Flohr KH, Goldman S, Cobb FR,
Shah PM, Saunders R, Fletcher RD, Loeb HS, Hughes VC, Baker B: Effect
of vasodilator therapy on mortality in chronic congestive heart failure: results
of a Veterans Administration Cooperative Study. N. Eng. J. Med.
1986;314:1547-1552.
26) Cohn JN, Johnson G, Ziesche S, Cobb F, Francis G, Tristani F, Smith
R, Duckman WB, Loeb H, Wong M, Bhat G, Goldman S, Fletcher RD,
Doherty J, Hughes CV, Carson P, Cintron G, Shabetai R, Haakenson C: A
comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment
of congestive heart failure. N. Engl. J. Med. 1991;325:303-310.
27) Cohn JN, Levine TB, Francis GS, Goldsmith S: Neurohumoral control
mechanisms in congestive heart failure. Am. Heart J. 1981;102:509-514.
28) Coleman HN, Sonnenblick HE, Braunwald E: Myocardial oxygen
consumption associated with external work: The Fenn effect. Am. J. Physiol.
1969;217:291-296.
29) Cryer PE: Physiology and pathophysiology of the human sympathoadrenal
neuroendocrine system. N. Engl. J. Med. 1980;303:436-444.
30) Daniel M, Noble MIM, ter Keurs HEDJ, Wohlfant B: Velocity of
sarcomere shortening in rat cardiac muscle: relationship to force, sarcomere
length, calcium and time. J. Physiol. (Lond.) 1984;355:367-381.
31) Davies RF, Beanlands DS, Nadeau C, Phaneuf D, Morris A, Arnold JM,
Parker JO, Baigrie RB, Latour O, Klinke WP, Bernstein V, Leblanc M,
Mizgala H, Stevens A, Boisvert G, C.E.V.D.S. G: Enalapril versus digoxin in
patients with congestive heart failure: a multicenter study. J. Am. Coll.
Cardiol. 1991;18:1602-1609.
32) Downing SE, Sonnenblick EH: Cardiac muscle mechanics and ventricular
performance: force and time parameters. Am. J. Physiol. 1964;207:705-715.
33) Dubois EL, Wallace DJ: Dubois’ Lupus Erythematosus., In ﾊed.
Philadelphia, Lea & Febiger, 1987, pp 318.
34) Ebashi S: Regulatory mechanism of muscle contraction with special
reference to the Ca-troponin-tropomyosin system., In Campbell P, Dickems F:
ﾊed. Essays in Biochemistry. London, Academic Press, 1974, pp 1-36. volﾊ10).
35) Ebashi S, Endo M: Calcium ion and muscular contraction. Prog. Biophys.
Mol. Biol. 1968;18:123-183.
36) Eisner DA, Lederer WJ, Vaughan-Jones RD: The control of tonic tension
by membrane potential and intracellular sodium activity in the sheep cardiac
Purkinje fibre. J. Physiol. (Lond.) 1983;335:723-743.
37) Elkayam U, Amin J, Mehra A, Vasquez J, Weber L, Rahimtoola SH: A
prospective, randomized, double-blind, crossover study to compare the
efficacy and safety of chronic nifedipine therapy to isosorbide dinitrate and
their combination in the treatment of chronic congestive heart failure.
Circulation 1990;82:1954-1961.
38) Elkayam U, Weber L, McKay C, Rahimtoola S: Spectrum of acute
hemodynamic effects of nifedipine in severe congestive heart failure. Am. J.
Cardiol. 1985;56:560-566.
39) Endoh M, Shibasaki T, Satoh H, Norota I, Ishihata A: Different
mechanisms involved in the positive inotropic effects of benzimidazole
derivative UD-CG 115 BS (pimobendan) and its demethylated metabolite UDCG
212 Cl in canine ventricular myocardium. J. Cardiovasc. Pharmacology
1991;17:365-375.
40) Evans CL, Matsuoka Y: The effect of various mechanical conditions on
the gaseous metabolism and efficiency of the mammalian heart. J. Physiol.
(Lond.) 1914;49: 378-405.
41) Fananapazir L, Cannon RO, Tripodi D, Panza JA: Impact of dualchamber
permanent pacing in patients with obstructive hypertrophic
cardiomyopathy with symptoms refractory to verapamil and b-adrenergic
blocker therapy. Circulation 1992;85:2149-2161.
42) Faxon DP, Creager MA, Halperin JL, Gravras H, Coffmann JD, Ryan
TJ: Central and peripheral hemodynamic effects of angiotensin inhibition in
patients with refractory congestive heart failure. Circulation 1980;61:925-930.
43) Feldman AH, Bristow MR, Parmley WW, Carson PE, Pepine CJ, Gilbert
EM, Strobeck JE, Hendrix GH, Powers ER, Bain RP, White BG: Effects of
vesnarinone on morbidity and mortality in patients with heart failure. N. Engl.
J. Med. 1993;329:149-155.
44) Feldman MD, Copelas L, Gwathmey JK, Phillips P, Warren SE, Schoen
FJ, Grossman W, Morgan JP: Deficient production of cyclic AMP:
Pharmacologic evidence of an important cause of contractile dysfunction in
patients with end-stage heart failure. Circulation 1987;75:331-339.
45) Fenn WO: A quantitative comparison between the energy liberated and
the work performed by the isolated sartorius muscle of the frog. J. Physiol.
(Lond.) 1923;58:175-203.
46) Ferguson DW: Digitalis and neurohormonal abnormalities in heart failure
and implications for therapy. Am. J. Cardiol. 1992;69:24G-33G.
47) Ferguson DW, Berg WJ, Sanders JS, Roach PJ, Kempf JS, Kienzle MG:
Sympatho-inhibitory responses to digitalis glycosides in heart failure patients:
direct evidence from sympathetic neural recordings. Circulation 1989;80:65-
77.
48) Ferlinz J, Gallo CT: Responses of patients in heart failure to long-term
oral verapamil administration (abstract). Circulation 1984;70(Suppl. II):II305.
49) Forester W, Lewis RP, Weissler AM, Wilke TA: The onset and magnitude
of the contractile response to commonly used digitalis glycosides in normal
subjects. Circulation 1974;49:517-521.
50) Francis GS, Goldsmith SR, Ziesche SM, Cohn JN: Response of plasma
norepinephrine and epinephrine to dynamic exercise in patients with
congestive heart failure. Am. J. Cardiol. 1982;49:1152-1156.
51) Frank O: Zur Dynamik des Heizmuskels. Zeitschrift fur Biologie
1885;32:370-447.
52) Fuzino K, Sperelakis N, Solaro RJ: Sensitization of dog and guinea pig
heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan:
comparison with milrinon. Circ. Res. 1988;63:911-922.
53) 藤山増昭, 高橋啓美, 板家守夫, 古田陽一郎, 緒方康博, 戸嶋裕徳, 宇津典彦: 圧変
化に伴う左室収縮末期圧ー内径関係の実験的，臨床的検討。Linearlityの問題と心
拍数との関連性について. 呼吸と循環 1980;28:1289-1297.
54) Garrod AH: On some points connected with the circulation of the blood,
arrived at from a study of the sphyngograph-trace. Proc. R. Soc. (Lond.) 1874-
1875;23:140-151.
55) Gheorghiade M, Ferguson D: Digoxin: a neurohormonal modulator in
heart failure? Circulation 1991;84:2181-2186.
56) Gheorghiade M, Hall V, Lakier JB, Goldstein S: Comparative
hemodynamic and neurohormonal effects of intravenous captopril and digoxin
and their combination in patients with severe heart failure. J. Am. Coll.
Cardiol. 1989;13:134-142.
57) Gibbs CL, Chapman JB: Cardiac mechanics and
energetics:chemomechanical transduction in cardiac muscle. Am. J. Physiol.
1985;249:H199-H206.
58) Gibbs CL, Gibson WR: Effect of ouabain on the energy output of rabbit
cardiac muscle. Circ. Res. 1969;24:951-967.
59) Gibbs CL, Gibson WR: Isoprenaline, propranolol, and the energy output
of rabbit cardiac muscle. Cardiovasc. Res. 1972;6:508-515.
60) Goldberg AD, Nicklas J, Goldstein S: Effectiveness of imazodan for
treatment of chronic congestive heart failure. Am. J. Cardiol. 1991;68:631-
636.
61) Goldstein RE, Boccuzzi SJ, Cruess D, Nattel S, the-Adverse-Experience-
Committee a-t-M-D-P-I-R-G: Diltiazem increases late-onset congestive heart
failure in postinfarction patients with early reduction in ejection fraction.
Circulation 1991;83:52-60.
62) Gordon AM, Pollack GH: Effects of calcium on the sarcomere lengthtension
relation in rat cardiac muscle. Circ. Res. 1980;47:610-619.
63) Goto Y, Slinker BK, LeWinter MM: Decreased contractile efficiency and
increased non-mechanical energy cost in hyperthyroid rabbit heart: relation
between O2 consumption and systolic pressure-volume area or force-time
integral. Circ. Res. 1990;66:999-1011.
64) Grossman W, Braunwald E, Mann T, McLaurin LP, Green LH:
Contractile state of the left ventricle in man as evaluated from end-systolic
pressure-volume relations. Circulation 1977;56:845-852.
65) Guyatt GH, Sullivan MJ, Thompson PJ, Fallen EL, Pugsley SO, Taylor
DW, Berman LB: The 6-minute walk: a new measure of exercise capacity in
patients with chronic heart failure. Can. Med. Assoc. J. 1985;132:919-923.
66) Gwathmey JK, Copelas L, MacKinnon R, Schoen FJ, Feldman MD,
Grossman W, Morgan JP: Abnormal intracellular calcium handling in
myocardium from patients with end-stage heart failure. Circ. Res. 1987;61:70-
76.
67) Hartree W, Hill AV: The regulation of the supply of energy in muscular
contraction. J. Physiol. (Lond.) 1921;55:133-158.
68) Hasenfuss G, Holubarsch C, Heiss HW, Rattert B, Just HJ: Influence of
the calcium-sensitizer UDCG-115 on hemodynamics and myocardial energetics
in patient with idiopathic dilated cardiomyopathy. Comparison with
nitoprussid. Basic Res. Cardiol. 1989;84 (Suppl. 1):225-233.
69) Hasenfuss G, Holubarsch CH, Heiss HW, Meinertz TH, Bonzel T, Wais
U, Lehmann M, Just H: Myocardial energetics in patients with dilative
cardiomyopathy. Influence of nitroprusside and enoximone. Circulation
1989;80:51-64.
70) Hasenfuss G, Just CHH, Blanchard E, Mulieri LA, Alpert NR: Energetic
aspects of inotropic interventions in rat myocardium. Basic Res. Cardiol.
1987;82 (Suppl. 2):251-259.
71) Hasenfuss G, Mulieri LA, Blanchard EM, Holubarsch C, Leavitt BJ,
Ittleman F, Alpert NR: Energetics of isometric force development in control
and volume-overload human myocardium: comparison with animal species.
Circ. Res. 1991;68:836-846.
72) Hasenfuss G, Mulieri LA, Holubarsch C, Pieske B, Just H, Alpert NR:
Energetics of calcium cycling in nonfailing and failing human myocardium.
Basic Res. Cardiol. 1992;87 (Suppl. 2):81-92.
73) Heyndrickx GR, Millard RW, McRitchie RJ, Maroko PR, Vatner SF:
Regional myocardial functional and electrophysiological alterations after brief
coronary artery occlusion in conscious dogs. J. Clinical Investigation
1975;56:975-985.
74) Hill AV: Length of muscle, and the heat and tension developed in an
isometric contraction. J. Physiol. (Lond.) 1925; 60:237-263.
75) Hill AV: The heat of shortening and the dynamic constants of muscle.
Proc. R. Soc. (Lond.) 1938;[Biol] 126:136-195.
76) Hill AV: First and last experiments in muscle mechanics.University Press,
1970, pp
77) Hisano R, Cooper G: Correlation of force-length area with oxygen
consumption in ferret papillary muscle. Circ. Res. 1987;61:318-328.
78) Hochleitner M, Hoertnagl H, Hoertnagl H, Fridrich L, Gschnitzer F:
Long-term efficacy of physiologic dual-chamber pacing in the treatment of
end-stage idiopathic dilated cardiomyopathy. Am. J. Cardiol. 1992;70:1320-
1325.
79) Hoh JFY, Rossmanith GH, Kwan LJ, Hamilton AM: Adrenaline increases
the rate of cycling of cross bridges in rat cardiac muscle as measured by
pseudo-random binary noise-modulated perturbation analysis. Circ. Res.
1988;62:452-461.
80) Holt JP: Regulation of the degree of emptying of the left ventricle by the
80) Holt JP: Regulation of the degree of emptying of the left ventricle by the
force of ventricular contraction. Circ. Res. 1957;5:281-287.
81) Holubarsch C, Goulette RP, Litten RZ, Martin BJ, Mulieri LA, Alpert
NR: The economy of isometric force development, myosin isozyme pattern
and myofibrillar ATPase activity in normal and hypothyroid rat myocardium.
Circ. Res. 1985;56:78-86.
82) Hosoya K, Takeda K, Masuda T, Takahashi M, Yagi S: Cross-bridge
activation rate constant in patients with sytemic lupus erythematosus.
submitted for publication 1995;.
83) Huxley AF, Niedergerke R: Structural changes in muscle during
contraction-Interference microscopy of living muscle fibers. Nature
1954;173:971-973.
84) Huxley HE, Hansen J: Changes in the cross-striations of muscle during
contraction and stretch and their structural interpretation. Nature
1954;173:973-976.
85) 井上通敏, 佐藤秀幸, 松山泰三, 尾崎 仁: 運動時の交感神経活性と心機能. 心臓
1986;18:742-753.
86) Jeanrenaud X, Goy JJ, Kappenberger L: Effects of dual-chamber pacing
in hypertrophic obstractive cardiomyopathy. Lancet 1992;339:1318-1323.
87) Jewell BR, Hanck DA: Effects of inotropic interventions on end systolic
length-force curve of cat ventricular muscle. Cardiovasc. Res. 1987;21:559-
564.
88) Just H: Effects of pimobendan in heart failure with special reference to
myocardial energetics. Therapeutic Research 1994;15:2539-2543.
89) Kadota R, Takeda K, Shimizu T, Nakamura Y, Yagi S: Afterloading
increases the left ventricular end-systolic force-length relation slope in dogs.
Jpn. Heart J. 1991;32:711-722.
90) Kass DA, Beyar R, Lankford E, Heard M, Maughan WL, Sagawa K:
Influence of contractile state on curvilinearity of in situ end-systolic pressurevolume
relations. Circulation 1989;76:167-178.
91) Katz AM: Physiology of the Heart.ﾊ(firstﾊed.) New York, Raven Press,
1977, pp :73-88.
92) Katz AM: Physiology of the Heart.ﾊ(secondﾊed.) New York, Raben Press,
1992, pp :347-349.
93) Katz LN: The performance of the heart. Circulation 1960;21:483-498.
94) Kawai C, Yui Y, Hoshino S, Sasayama S, Matsumoto A: Myocardial
catecholamines in hypertrophic and dilated (congestive) cardiomyopathy: A
biopsy study. J. Am. Coll. Cardiol. 1983;2:834-840.
95) 木川田隆一: 心機図とその臨床.東京, 新興医学出版社, 1979, pp
96) Kirlin PC, Grekin R, Das S, Ballor E, Johnson T, Pitt B: Neurohumoral
activation during exercise in congestive heart failure. Am. J. Med.
1986;81:623-629.
97) Kono K, Takeda K, Taniguchi Y, Yagi S: Effect of chronic cardiac pacing
on cross-bridge activation rate in the human left ventricle. J. Cardiol.
1994;24:141-148.
98) Kubo SH, Gollub S, Bourge R, Rahko P, Cobb F, Jessup M, Brozena S,
Brodsky M, Kirlin P, Shanes J, Konstam M, Gradman A, Morledge J,
Cinquegrani M, Singh S, LeJemtel T, Nicklas J, Troha J, Cohn JN:
Beneficial effects of pimobendan on exercise tolerance and quality of life in
patients with heart faikure. Circulation 1992;85:942-949.
99) Kurihara S, Konishi M: Effects of b-adrenoceptor stimulation on
intracellular Ca transients and tension in rat ventricular muscle. Pflugers Arch.
1987;409:427-437.
100) 栗原 敏:心筋細胞内Ca動態と収縮制御. In:杉本恒明, 有田 眞,ed. Caと循環
器疾患フォーラム（第３回）. 東京，経団連会館: 1994
101) Lake CR, Ziegler MG, Kopin IJ: Use of plasma norepinephrine for
evaluation of sympathetic neuronal function in man. Life Sci. 1976;18:1315-
1326.
102) Langer GA, Brady AJ: The effects of temperature upon contraction and
ionic exchange in rabbit ventricular myocardium. Relation to control of active
state. J. Gen. Physiol. 1968;52:682-713.
103) Leach JK, Brady AJ, Skipper BJ, Millis DL: Effects of active shortening
on tension development of rabbit papillary muscle. Am. J. Physiol. 1980;238:
H8-H13.
104) Lehninger AL: Biochemistry.New York, Worth Publishers, 1975, pp :183-
216.
105) Leimbach WN: Direct evidence from intraneural recordings for increased
central sympathetic outflow in patients with heart failure. Circulation
1986;73:913-919.
106) Lewis RP, Boudoulas H, Forester WF, Weissler AM: Shortening of
electromechanical systole as a manifestation of excessive adrenergic
stimulation in acute myocardial infarction. Circulation 1972;46:856-862.
107) Lewis RP, Boudoulas H, Welch TD, Forester WF: Usefulness of systolic
time intervals in coronary artery disease. Am. J. Cardiol. 1976;37:787-796.
108) Lewis RP, Rittgers SE, Forester WF, Boudoulas H: A critical review of
the systolic time intervals. Circulation 1977;56:146-158.
109) Lipkin DP, Scriven AJ, Crake T, Poole-Wilson PA: Six minute walking
test for assessing exercise capacity in chronic heart failure. Br. Med. J.
1986;292:653-655.
110) Little WC, Freeman GL, O’Rourke RA: Simultaneous determination of
left ventricular end-systolic pressure-volume and pressure-dimension
relationships in closed-chest dogs. Circulation 1985;71:1301-1308.
111) Loiselle DS: The effects of temperature on the energetics of rat papillary
muscle. Pflugers. Arch. 1979;379:173-180.
112) Loiselle DS, Wendt IR, Hoh JFY: Energetic consequences of thyroidmodulated
shifts in ventricular isomyosin distribution in the rat. J. Muscl. Res.
Cell Motil. 1982;3:5-23.
113) Lombard WP, Cope OM: The duration of the systole of the left ventricle
of man. Am. J. Physiol. 1926;77:263-295.
114) Mahler F, Covell JW, Ross J: Systolic pressure-diameter relations in the
normal conscious dog. Cardiovasc. Res. 1975;9:447-455.
115) Marsh JD, Green LH, Wynne J, Cohn PF, Grossman W: Left
ventricular end-systolic pressure-dimension and stress-length relations in
normal human subjects. Am. J. Cardiol. 1979;44:1311-1319.
116) Masuda T, Takeda K, Hosoya K, Yagi H, Yagi S: Effects of Ca2+ channel
blocker, manidipine, on the canine left ventricular force-length relationship
during regional ischemia and after reperfusion. submitted for publication
1995;.
117) 益田俊英, 竹田幸一, 岡村 篤, 玉野宏一, 中村泰之, 八木 繁: 心不全の左室力
ー長さ関係. J. Cardiol. 1993;23:371-378.
118) 松原広己, 高木 都, 菅 弘之: 心不全とはー心機能及び心筋エネルギー効率の
立場からー. Current Topics in Cardiology 1993;5:16-29.
119) McDonald RH, Taylor RR, Cingolani HE: Measurement of myocardial
developed tension and its relation to oxygen consumption. Am. J. Physiol.
1966;211:667-673.
120) Mehmel HC, Stockins B, Ruffmann K, Olshausen KV, Schuler G,
Kubler W: The linearity of the end-systolic pressure-volume relationship in
man and its sensitivity for assessment of left ventricular function. Circulation
1981; 63:1216-1222.
121) Mirsky I, Tajimi T, Peterson KL: The development of the entire endsystolic
pressure-volume and ejection fraction-afterload relations: a new
concept of systolic myocardial stiffness. Circulation 1987;76:343-356.
122) Monroe RG, Strang RH, LaFarge CG, Levy J: Ventricular performance,
pressure-volume relationships, and O2 consumption during hypothermia. Am.
J. Physiol. 1964;206:67-73.
123) Morgan JP, Wier WG, Hess P, Blinks JR: Influence of Ca++-channel
blocking agents on calcium transients and tension development in isolated
mammalian heart muscle. Circ. Res. 1983;52 (Suppl. I):47-52.
124) 永井良三: 心筋収縮と心不全の分子機構. 日本内科学会雑誌 1994;83:3-8.
125) 永野 允: 座談会：心肥大をめぐって. 治療学 1992;26:1491-1501.
126) Nakamura Y, Takeda K, Kadota R, Masuda T, Yagi S: Effect of
isosorbide dinitrate infusion on the canine left ventricular force-length
relationship. Jpn. Heart J. 1993;34:91-101.
127) Nakamura Y, Wiegner AW, Gaasch WH, Bing OL: Systolic time
intervals: assessment by isolated cardiac muscle studies. J. Am. Coll. Cardiol.
1983;2:973-978.
128) 西山泰生, 竹田幸一, 中村泰之, 益田俊英, 八木 繁: Vesnarinoneのイヌin
situ左室心筋力ー長さ関係への効果. J. Cardiol. 1994;24:149-154.
129) Osakada G, Hess OM, Gallagher KP, Lavelle JF, Kemper WS, Ross. J:
End-systolic wall thickness-pressure, and wall thickness-stress relations for
assessing myocardial contractility (abstract). Circulation 1980;62 (Suppl.
3):203.
130) Packer M: Treatment of chronic heart failure. Lancet 1992;340:92-94.
131) Packer M, Carver JR, Rodeheffer RJ, al e: Effect of oral milrinone on
mortality in severe chronic heart failure. N. Engl. J. Med. 1991;325:1468-
1475.
132) Packer M, Gheorghiade M, Young JB, Costantini PJ, Adams KF, Cody
RJ, Smith LK, Voorhees LV, Gourley LA, Jolly MK: Withdrawal of digoxin
from patients with chronic heart failure treated with angiotensin-convertingenzyme
inhibitors. N. Engl. J. Med. 1993;329:1-7.
133) Paganini ED, Alousi AA, Grant AM, Order TM, Dziuban SW, Allen
PD: Changes in myofibrillar content and Mg-ATPase activity in ventricular
tissues from patients with heart failure caused by coronary artery disease,
cardiomyopathy, or mitral valve insufficiency. Circ. Res. 1988;63:380-385.
134) Patterson SW, Piper H, Starling EH: The regulation of the heart beat. J.
Physiol. (Lond.) 1914;48:465-513.
135) Patterson SW, Starling EH: On the mechanical factors which determine
the output of the ventricles. J. Physiol. (Lond.) 1914;48:357-379.
136) Pfeffer MA, Braunwald E, Moye LA, Basta L, Brown EJ, Cuddy TE,
Davis BR, Geltman EM, Goldman S, Flaker GC, Klein M, Lamas GA,
Packer M, Rouleau J, Rouleau JL, Rutherford J, Wertherimer JH, Hawkins
CM, on-Behakf-of-the-SAVE-Investigators: Effect of captopril on mortality
and morbidity in patients with left ventricular dysfunction after myocardial
infarction. N. Engl. J. Med. 1992;327:669-677.
137) Pollack GH, Krueger JW: Sarcomere dynamics in intact cardiac muscle.
Eur. J. Cardiol. 1976;4 (Suppl. 53):61-65.
138) Pool PE, Chandler BM, Seagren SC, Sonnenblick HE:
Mechanochemistry of cardiac muscle. The isotonic contraction. Circ. Res.
1968;22:465-472.
139) Pouleur H, Rousseau MF, Eyll CV, Mechelen HV, Brasseur LA,
Charlier AA: Assessment of left ventricular contractility from late systolic
stress-volume relations. Circulation 1982; 65:1204-1212.
140) Rall JA: Sense and nonsense about the Fenn effect. Am. J. Physiol.
1982;242:H1-H6.
141) Ross J, Franklin D: Analysis of regional myocardial function,
dimensions, and wall thickness in the characterization of myocardial ischemia
and infarction. Circulation 1976;53:I88-I92.
142) Safar ME, Lehner JP, Vincent MI, Plainfosse MT, Simon A:
Echocardiographic dimensions in borderline and sustaind hypertension. Am.
J. Cardiol. 1979;44:930-935.
143) Sagawa K, Maughan WL, Burkhoff D, Yue D: The similarity between
ventricular pressure-volume relation and muscle force-length relation
(abstract). Cardiovasc. Res. 1985;19:523.
144) Sarnoff SJ, Braunwald E, Welch GH, Case RB, Stainsby WN, Macruz
R: Hemodynamic determinants of oxygen consumption of the heart with
special reference to the tension-time index. Am. J. Physiol. 1958;192:148-156.
145) Sasayama S, Asanoi H, Kihara Y, Yokawa S, Terada Y, Yoshida S, Ejiri
M, Horikoshi I: Clinical effects of long-term administration of pimobendan in
patients with moderate congestive heart failure. Heart Vessels 1994;9:113-120.
146) Sasayama S, Franklin D, Ross J: Hyperfunction with normal inotropic
state of the hypertrophied left ventricle. Am. J. Physiol. 1977;232:418.
147) Seals DR, Victor RG, Mark AL: Plasma norepinephrine and muscle
sympathetic discharge rhythmic exercise in humans. J. Appl. Physiol.
1988;65:940-944.
148) Silverberg AB, Shah SD, Haymond MW, Cryer PE: Norepinephrine:
hormone and neurotransmitter in man. Am. J. Physiol. 1978;234:E252-E256.
149) Sonnenblick EH: Force-velocity relations in mammalian heart muscle.
Am. J. Physiol. 1962;202:931-939.
150) Sonnenblick EH: Instantaneous force-velocity-length determinants in the
contraction of heart muscle. Circ. Res. 1965;16:441-451.
151) Suga H: Left ventricular time-varying pressure/volume ratio in systole as
an index of myocardial inotropism. Jpn. Heart J. 1971;12:153-160.
152) Suga H: Total mechanical energy of a ventricle model and cardiac
oxygen consumption. Am. J. Physiol. 1979;236:H498-H505.
153) Suga H, Goto Y, Igarashi Y, Yasumura Y, Nozawa T, Futaki S, Tanaka
N: Cardiac cooling increases Emax without affecting relation between O2
consumption and systolic pressure-volume area in dog left ventricle. Circ. Res.
1988;63:61-71.
154) Suga H, Goto Y, Yamada O, Igarashi Y: Left ventricular pressure-volume
relationship and energetics.Tokyo, Japan Scientific Societies Press, 1986, pp
:111-119. (Kitamura K, Abe H, Sagawa K,ﾊed. New Approaches in Cardiac
Mechanics
155) Suga H, Hayashi T, Suehiro S, Hisano R, Shirahata M, Ninomiya I:
Equal oxygen consumption rates of isovolumic and ejecting contractions with
equal systolic pressure-volume areas in canine left ventricle. Circ. Res.
1981;49:1082-1091.
156) Suga H, Hisano R, Goto Y, Yamada O: Normalization of end-systolic
pressure-volume relation and Emax of different sized hearts. Jpn. Circ. J.
1984;48:136-143.
157) Suga H, Hisano R, Goto Y, Yamada O, Igarashi Y: Effect of positive
inotropic agents on the relation between oxygen consumption and systolic
pressure volume area in canine left ventricle. Circ. Res. 1983;53:306-318.
158) Suga H, Sagawa K: Mathematical interrelationship between
instantaneous ventricular pressure-volume ratio and myocardial force-velocity
relation. Ann. Biomed. Eng. 1972;1:160-181.
159) Suga H, Sagawa K: Instantaneous pressure-volume relationships and
their ratio in the excised, supported canine left ventricle. Circ. Res. 1974;
35:117-126.
160) Suga H, Sagawa K, Shoukas AA: Load independence of the
instantaneous pressure-volume ratio of the canine left ventricle and effects of
epinephrine and heart rate on the ratio. Circ. Res. 1973;32:314-322.
161) Suga H, Tanaka N, Ohgoshi Y, Saeki Y, Nakanishi T, Futaki S, Yaku
H, Goto Y: Hyperthyroid dog left ventricle has the same oxygen consumption
versus pressure-volume area (PVA) relation as euthyroid. Heart Vessels
1991;6:71-88.
162) Suga H, Yamada O, Goto Y, Igarashi Y, Yasumura Y, Nozawa T:
Reconsideration of normalization of Emax for heart size. Heart Vessel
1986;2:67-73.
163) 菅 弘之: 心室圧ー容積面積と酸素消費量, In 菅 弘之, 堀 正二: ed. 心臓の
適応と制御. 東京, 朝倉書店, 1992, pp 218-230.
164) Sunagawa K, Maughan WL, Friesinger G, Guzmar P, Chang M,
Sagawa K: Effect of coronary arterial pressure on left ventricular end-systolic
pressure-volume relation of isolated canine heart. Circ. Res. 1982;50:727-734.
165) Sunagawa K, Maughan WL, Sagawa K: Effect of regional ischemia on
the left ventricular end-systolic pressure-volume relationship of isolated canine
hearts. Circ. Res. 1983;52:170-178.
166) 高橋正樹, 竹田幸一, 早乙女孝子, 小林直彦, 八木 繁: 心不全における6分間歩
行後の連結橋活性化速度の変化. J. Cardiol. 印刷中 1994
167) Takahashi M, Sasayama S, Kawai C, Kotoura H: Contractile
performance of the hypertrophied ventricle in patients with systemic
hypertension. Circulation 1980; 62:116-126.
168) Takeda K: Active cross-bridge model: reproduction of the myocardial
force-length-time relation and the left ventricular pressure-length-time relation
in systole. Jpn. Heart J. 1990;31:43-69.
169) Takeda K, Kadota R, Yagi S: Time-varying myocardial elastance of
canine left ventricle. Am. J. Physiol. (Heart & Circ. Physiol.) 1991;261:H1554-
H1562.
170) Takeda K, Kono K, Tamano K, Takahashi M, Nakamura Y, Masuda T,
Hosoya K, Yoshihara T, Yagi S: New interpretation of systolic time intervals
from active cross-bridge model. Jpn. Circ. J. 1993;57:299-311.
171) Takeda K, Masuda T, Nakamura Y, Hosoya K, Yagi S: Effect of regional
ischemia on force-length relationship of canine left ventricle according to
cross-bridge model. Dokkyo J. Med. Sci. in press 1995;22.
172) Takeda K, Nakamura Y, Kono K, Ogawa Y, Takahashi M, Oyama M,
Masuda T, Yagi S: A contractility index independent of myocardial length.
Jpn. Circ. J. 1992;56:722-724.
173) Takeda K, Shimizu T, Nakamura Y, Masuda T, Kono K, Takahashi M,
Oyama M, Yagi S: Effect of alpha1-adrenoceptor blockade on the left
ventricular force-length relationship in dogs. Jpn. Circ. J. 1992;56:929-935.
174) Takeda K, Shimizu T, Yamamoto H, Yagi S: Human left ventricular
end-systolic pressure-volume relationship in a cylinder model. Jpn. Heart J.
1988;29:689-707.
175) Takeda K, Takeda M, Shimizu T, Yagi S: Approximation of various
canine left ventricular end-systolic relations by a cylinder model. Am. J.
Physiol. (Heart & Circ. Physiol.) 1990;258:H1300-H1311.
176) Takeda K, Tamano K, Okamura A, Kobayashi N, Shimizu T, Kadota
R, Yamamoto H, Yagi S: Slope of human left ventricular end-systolic forcelength
relation is independent of myocardial length. Am. J. Physiol. (Heart &
Circ. Physiol.) 1991;261:H1060-H1066.
177) Takeda K, Yagi S: Cross-bridge cycling energy of cardiac muscle
estimated from an active cross-bridge model. Jpn. Heart J. 1991;32:69-89.
178) 竹田幸一: 化学反応速度論と活性連結橋モデルの基本仮説. 循環器科
1991;29:312-316.
179) 竹田幸一: 心室の収縮特性. In 菅 弘之, 堀 正二,ed. 心臓の適応と制御， 東
京, 朝倉書店, 1992, pp 59-66.
180) 竹田幸一, 岡村 篤, 玉野宏一, 小林直彦, 門田隆太郎, 中村泰之, 永島和幸, 西
山泰之, 山本英雄, 八木 繁: ニトログリセリン静注で心筋収縮性が低下した虚血性
心筋症の一例. J. Cardiol. 1990;20:1037-1043.
181) 竹田幸一, 八木 繁: 左室心筋収縮性の新しい視点｡心筋の力ｰ長さ関係と左室
収縮末期関係の理論的統合. 循環器科 1989;26:233-244.
182) 竹内正喜, 上田裕司, 関岡清次, 小西得司, 中野 赴: 左室エナジェテクスから
評価したshortening activationとshortening deactivation（抄録）. Jpn. Circ. J.
1992;56 (Suppl. I):72.
183) 滝島 任, 石出信正: 心力学とその臨床.東京, 文光堂, 1983
184) 谷川 直, 渡辺一郎, 高橋義和, 国本 聡, 斉藤 穎, 小沢友紀夫: 永久ペースメ
ーカー植込み後発症する無症候性左心機能不全についての検討（抄録）. J.
Cardiol. 1994;24:47.
185) 谷口洋子, 杉原洋樹, 寺田幸治, 伊藤一貴, 大槻克一, 志賀浩治, 志真孝友, 中村
隆志, 東 秋弘, 河野義雄, 中川雅夫, 宮尾賢爾: 心尖部肥大型心筋症の心筋虚血と心
臓交感神経機能異常の検討. J. Cardiol. 1994;24:293-298.
186) Tavel ME: Clinical Phonocardiography & External Pulse
Recording.ﾊ(3ﾊed.) Chicago, Year Book Medical Publisher, 1978, pp
187) Taylor RR, Covell JW, Ross J: Volume-tension diagrams of ejecting and
isovolumic contractions in left ventricle. Am. J. Physiol. 1969;216:1097-1102.
188) Tennant R, Wiggers CJ: The effect of coronary occlusion on myocardial
contraction. Am. J. Physiol. 1935;112:351-361.
189) ter Keurs HEDJ, Rijnsburger WH, von Heuningen R, Nogelsmit MJ:
Tension development and sarcomere length in rat cardiac trabeculae:
Evidence of length-dependent activation. Circ. Res. 1980;46:703-714.
190) The Captoril Digoxin Multicenter Research Group: Comparative effects
of therapy with captoril and digoxin in patients with mild to moderate heart
failure. JAMA 1988;259:539-544.
191) The CONSENSUS Trial Study Group: Effects of enalapril on mortality in
severe congestive heart failure: results of the Cooperative North Scandinavian
Enalapril Survival Study (CONSENSUS). N. Engl. J. Med. 1987;316:1429-1435.
192) The Multicenter Diltiazem Postinfarction Trial Research Group: The
effect of diltiazem on mortality and reinfarction after myocardial infarction. N.
Eng. J. Med. 1988;319:385-392.
193) The SOLVD Investigators: Effect of enalapril on survival in patients with
reduced left ventricular ejection fractions and congestive heart failure. N.
Engl. J. Med. 1991;325:293-302.
194) The SOLVD Investigators: Effect of enalapril on mortality and the
development of heart failure in asymptomatic patients with reduced left
ventricular ejection fractions. N. Engl. J. Med. 1992;327:685-691.
195) The Xamoterol in Severe Heart Failure Study Group: Xamoterol in
severe heart failure. Lancet 1990;336:1-6.
196) Theroux P, Franklin D, Ross JJ, Kemper WS: Regional myocardial
function during acute coronary artery occlusion and its modification by
pharmacologic agents in the dog. Circ. Res. 1974;35:896-908.
197) Theroux P, Ross JJ, Franklin D, Kemper WS, Sasayama S: Regional
myocardial function in the conscious dog during acute coronary occlusion and
responses to morphine, propranolol, nitroglycerin, and lidocaine. Circulation
1976;53:302-314.
198) Toombs CF, Johansen JV, Yokoyama H, Johnston WE, Julian JS,
Cordell AR: Nonlinearlity of indexes of left ventricular performance: effects
on estimation of slope and diameter axis intercepts. Am. J. Physiol.
1991;260:H1802-H1809.
199) Toutouzas P, Gupta D, Samson R, Shillingford J: Q-second sound
interval in acute myocardial infarction. Br. Heart J. 1969;31:462-467.
200) Uretsky BF, Jessup M, Konstam MA, Dec GW, Leier CV, Benotti J,
Murali S, Herrmann HC, Sandberg JA: Multicenter trial of oral enoximone in
patients with moderate to moderately severe congestive heart failure: lack of
patients with moderate to moderately severe congestive heart failure: lack of
benefit compared with placebo. Circulation 1990;82:774-780.
201) 臼井 孝, 柏木政伸, 八鍬秀之, 山田亜樹, 上野 淳, 下津順子: ペースメーカー
植込み症例における123I-metaiodobenzylguanidine心筋像についての検討（抄
録）. 日本内科学会雑誌 1994;83:245.
202) Waagstein F, Caidahl K, Wallentin I, Bergh C, Hjalmarson A: Longterm
beta-blockade in dilated cardiomyopathy: effects of short- and long-term
metoprolol treatment followed by withdrawal and readministration of
metoprolol. Circulation 1989;80:551-563.
203) Waagstein F, Hjalmarson A, Varnauskas E, Wallentin I: Effect of
chronic beta-adrenergic receptor blockade in congestive cardiomyopathy. Br.
Heart J. 1975;37:1022-1036.
204) 渡辺浩毅, 関谷達人, 池田俊太郎, 木下正之, 有光克次郎, 阿久津弘, 井町恒雄:
肥大型心筋症に対するDDDRペースメーカー治療の左室拡張機能に及ぼす変化につ
いての検討（抄録）. J. Cardiol. 1994;24:46.
205) Weber KT, Janicki JS, Hefner LL: Left ventricular force-length relations
of isovolumic and ejecting contractions. Am. J. Physiol. 1976;231:337-343.
206) Weissler AM, Harris WS, Schoenfeld CD: Systolic time intervals in
heart failure in man. Circulation 1968;37:149-159.
207) Weissler AM, Harris WS, Schoenfeld CD: Bedside technics for the
evaluation of ventricular function in man. Am. J. Cardiol. 1969;23:577-583.
208) Weissler AM, Snyder JR, Schoenfeld CD, Cohen S: Assay of digitalis
glycosides in man. Am. J. Cardiol. 1966;17:768-780.
209) Westfall MV, Wahler GM, Solaro RJ: A high specific benzimidazole
pyridazinone phosphate-induced changes in cardiac myofilament activation.
Biochemistry 1993;32:10464-10470.
210) Wiggers CJ: Studies on the consecutive phases of the cardiac cycle.2.
The laws governing the relative durations of ventricular systole and diastole.
Am. J. Physiol. 1921;56:439-459.
211) Winegrad S, Weisberg A, Lin LE, McClellan G: Adrenergic regulation of
myosin adenosine triphosphatase activity. Circ. Res. 1986;58:83-95.
212) Winnem M, Piene H: Left ventricular end-systolic pressure volume
relations in healthy young man. Europ. Heart J. 1986;7:961-972.
213) Yeatman LA, Parmley WW, Sonnenblick EH: Effects of temperature on
series elasticity and contractile element motion in heart muscle. Am. J.
Physiol. 1969;217:1030-1034.
214) 吉原光恵, 竹田幸一, 門田隆太郎, 中村泰之, 八木 繁: プロプラノロールのイ
ヌin situ左室力ー長さ関係への効果. J. Cardiol. 1992;22:211-217.
215) Young BJ, Uretsky BF, Shahidi FE, Yellen LG, Harrison MC, Jolly MK:
Multicenter, double-blind, placebo-control randomized withdrawal trial of the
efficacy and safety of digoxin in patients with mild to moderate chronic heart
failure not treated with converting enzyme inhibitors (abstract). J. Am. Coll.
Cardiol. 1992;19:259A.
216) Yue D: Intracellular [Ca2+] related to rate of force development in twitch
contraction of heart. Am. J. Physiol. 1987;252:H760-H770.
217) Yusuf S, Pepine CJ, Garces C, Pouleur H, Salem D, Kostis J, Benedict
C, Rousseau M, Bourassa M, Pitt B: Effect of enalapril on myocardial
infarction and unstable angina in patients with low ejection fractions. Lancet
1992;340:1173-1178.7